Physiological Intracytoplasmic Sperm Injection (PICSI)

PICSI (Physiological Intracytoplasmic Sperm Injection) is an added sperm selection device when it comes to ICSI, that works to select the best possible sperm for fertilisation in IVF. 

This is important because the better the quality of the sperm, the better the chance of a successful fertilisation. PICSI is based on a concept called Hyaluronan which is a matter found in most parts of the body, including the binding that surrounds the female egg. This process selects sperm according to how well they bind to the Hyaluronan around the egg cell, through a test called a Hyaluronan Binding Assay. 

While sperm is traditionally selected for ICSI based on its appearance, PICSI allows a selection based on the sperm’s ability to fertilise and function. This nullifies the concern around the fact that chromosomal defects can still be found within healthy-looking sperm. PICSI and ICSI has dramatically improved the treatment of male infertility, and has allowed many men to become biological fathers who otherwise would not have been able to conceive with their partner.

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